diff --git a/matrix_alertbot/callback.py b/matrix_alertbot/callback.py
index 8db1d3c..385db72 100644
--- a/matrix_alertbot/callback.py
+++ b/matrix_alertbot/callback.py
@@ -96,7 +96,7 @@ class Callbacks:
             user_id_patterns.append(rf"@?{username}(:{homeserver})?")
 
         pattern = re.compile(
-            rf"(^|\s+)({'|'.join(user_id_patterns)})(\s+|$)",
+            rf"(^|\s+)({'|'.join(user_id_patterns)}):?(?=\s+|$)",
             re.IGNORECASE | re.MULTILINE,
         )
         if pattern.search(msg) is None:
@@ -123,6 +123,11 @@ class Callbacks:
 
         # Remove the mention of the bot
         cmd = pattern.sub(" ", msg).strip()
+        logger.debug(
+            "Bot {self.matrix_client.user_id} | Room ID {room.room_id} | "
+            f"Event ID {event.event_id} | Sender {event.sender} | "
+            f"Processing command {cmd}"
+        )
         try:
             command = CommandFactory.create(
                 cmd,
diff --git a/tests/test_callback.py b/tests/test_callback.py
index 4fdbab1..4510909 100644
--- a/tests/test_callback.py
+++ b/tests/test_callback.py
@@ -307,6 +307,39 @@ class CallbacksTestCase(unittest.IsolatedAsyncioTestCase):
         )
         fake_command.return_value.process.assert_called_once()
 
+    @patch.object(matrix_alertbot.command, "AckAlertCommand", autospec=True)
+    async def test_message_ack_in_reply_with_multi_mentions(
+        self, fake_command: Mock
+    ) -> None:
+        """Tests the callback for RoomMessageText with a mention of the bot"""
+        # Tests that the bot process messages in the room that contain a command
+        fake_message_event = Mock(spec=nio.RoomMessageText)
+        fake_message_event.event_id = "some event id"
+        fake_message_event.sender = "@some_other_fake_user:example.com"
+        fake_message_event.body = "@fake_user:example.com @fake_user:example.com: ack"
+        fake_message_event.source = {
+            "content": {
+                "m.relates_to": {"m.in_reply_to": {"event_id": "some alert event id"}}
+            }
+        }
+
+        # Pretend that we received a text message event
+        await self.callbacks.message(self.fake_room, fake_message_event)
+
+        # Check that the command was not executed
+        fake_command.assert_called_once_with(
+            self.fake_matrix_client,
+            self.fake_cache,
+            self.fake_alertmanager_client,
+            self.fake_config,
+            self.fake_room,
+            fake_message_event.sender,
+            fake_message_event.event_id,
+            "some alert event id",
+            (),
+        )
+        fake_command.return_value.process.assert_called_once()
+
     @patch.object(matrix_alertbot.callback, "UnackAlertCommand", autospec=True)
     async def test_message_unack_not_in_reply_with_mention(
         self, fake_command: Mock